- The protein NSD2 has been identified as a key factor in prostate cancer development when it binds with the androgen receptor, leading to rapid cell division and growth
- Researchers used a combination of techniques, including CRISPR screening, to study the interaction between NSD2 and the androgen receptor in prostate cancer cells
- Another study debunks the myth linking choline intake to increased prostate cancer risk, highlighting the limitations of the original observational study that suggested this connection
- Poor mitochondrial health, influenced by excess linoleic acid intake, endocrine-disrupting chemicals and electromagnetic field exposure, are the likely root causes of major diseases, including cancer
- Aspirin, particularly immediate-release formulations, has anticancer properties. Low doses taken consistently over long periods show benefits in reducing cancer risk
(Mercola)—According to the American Cancer Society, about 1 in 8 men will be diagnosed with prostate cancer during their lifetime. It’s the second-leading cause of cancer death behind lung cancer.1 But despite its prevalence, a diagnosis is not an automatic death sentence.
Between 1993 and 2013, the death rate of prostate cancer declined by around half, and 3.3 million American men diagnosed with this disease at some point are still alive.2 Furthermore, the National Cancer Institute predicts a 97.5% survival rate after diagnosis.3 But, we’re not out of the woods yet — plenty of research is still being done to learn more about treating this disease, and researchers from the University of Michigan have just pushed the frontier.
NSD2 Protein Implicated as an Activator of Prostate Cancer
In a study4 published in Nature Genetics, researchers discovered a key factor in the development of prostate cancer. Specifically, they noted that when the NSD2 (nuclear receptor binding SET Domain Protein 2) binds with the androgen receptor (AR), it leads to rapid cell division and growth that results in prostate cancer.
Before diving further into this, let’s define some of the basics. Androgens are essentially hormones that trigger the growth and development of the male reproductive system, and the most prominent example is testosterone. They’re responsible for the changes that males go through during puberty, such as thickening of the vocal cords that leads to a deeper voice.5
While androgens are largely associated with males, females produce androgens as well, but in smaller amounts. When androgens are released, they’re converted into estradiol, a type of estrogen. In this converted state, estradiol helps regulate menstruation, as well as conception and pregnancy.6
Now, what is the AR? It’s essentially a protein produced by the AR gene, which then binds to the androgens produced in your body. As noted by MedlinePlus:7
“The receptors are present in many of the body’s tissues, where they attach (bind) to androgens. The resulting androgen-receptor complex then binds to DNA and regulates the activity of certain genes that play a role in male sexual development. By turning the genes on or off as necessary, the androgen receptor complex helps direct the development of male sex characteristics.”
Going back to the Nature Genetics study,8 the researchers were able to crack the code, as it were, between NSD2 and AR using an epigenetics-targeted functional CRISPR (clustered regularly interspaced short palindromic repeats) screening. Interestingly, they noted that NSD2 is also an oncogene in hematologic cancers, and “harbors recurrent activating alterations in over 15% to 20% of multiple myeloma and 10% childhood acute lymphoblastic leukemia.”
Diving Deeper Into the Development of Prostate Cancer
The researchers used different methodologies that comprised human and animal test samples. For human samples, prostate tumor patient tissues were taken from the archives of University of Michigan archives, while mice were provided by the University of Pennsylvania and the University of Michigan, which were kept under humane conditions.9 After completing their assays and analysis, the researchers published these findings:10
“Conventional plasmid-based reporter systems fail to capture intricate epigenetic or chromatin-level regulation of gene expression as they lack the native histone composition or higher-order chromosomal structure. Thus, we engineered an endogenous AR reporter system by using the CRISPR/Cas9 and homologous recombination methodologies.
We edited the KLK3 gene (also known as prostate-specific antigen, PSA) locus in AR-driven LNCaP cells to knock-in the mCherry coding sequence directly downstream of the endogenous promoter and fused in-frame via an endopeptidase sequence to the KLK3 gene …
Using these endogenous AR reporter cell lines, we carried out a functional CRISPR screen, wherein we treated the cells with a custom single guide RNA (sgRNA) library targeting druggable transcriptional cofactors for eight days, stimulated with DHT for 16 h and FACS-sorted into mCherryHIGH and mCherryLOW populations.
Genomic sgRNAs were sequenced and the ratio of normalized counts in mCherryLOW to mCherryHIGH cell populations was used to rank individual sgRNAs. Here, ranked alongside BRD4 and TRIM24, we identified NSD2 as an AR coactivator.”
The study is packed with dense information largely meant for oncology researchers, but the findings above summarize how the researchers were able to sift through large swaths of information and methodologies. Undoubtedly, this new breakthrough will be beneficial for all people receiving prostate cancer treatments.
The researchers concluded that NSD2 plays an important role in the development of prostate cancer. Furthermore, they proposed targeting this protein in further experiments to fully confirm the effectiveness of their findings. In a press release, co-author Dr. Arul M. Chinnaiyan elucidates further:11
“By degrading NSD1 and NSD2, we can more directly target cancer and avoid the normal tissue. Our study suggests if we’re able to develop NSD1/2-targeting agents, they could potentially be combined with FDA-approved androgen receptor antagonists and have a synergist effect in terms of treatment.”
Choline Does NOT Cause Prostate Cancer
Considering the new information published, I’d like to debunk a medical myth about prostate cancer that’s been circulating for a few years now — choline intake and its association with this disease.
The primary study where this notion came from,12 published in 2012, suggested there might be a link between increased choline intake and an increased risk of advanced, lethal prostate cancer. As noted by the authors, “Men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer.” However, there are several questionable aspects surrounding this conclusion.
To start, the study was observational only, which means it only suggests associations but cannot prove causation. Since there are many factors, both dietary and environmental, that play a big role in predicting prostate cancer outcomes, pinning the disease to a single nutrient is problematic.
Furthermore, the researchers collected dietary information only six times during 22 years of follow-ups, which raises questions about the accuracy of their collated information. Many people can’t even recall what they ate several days ago, let alone the foods they consumed within a span of 22 years. Other shortcomings of this study include the following:
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- It does not account for other components of the diet that could influence prostate cancer risk, such as phytonutrients, fiber and other vitamins and minerals.
- No dose-response relationship across quintiles of choline intake was established. Understanding whether the risk of prostate cancer increases linearly with choline intake or if there’s a threshold effect would be crucial for dietary recommendations.
- The study also looked at post-diagnostic intake of choline and its relationship with lethal prostate cancer among men who were initially diagnosed with nonmetastatic disease and here, no statistically significant link could be found.
In truth, choline is beneficial for your health. Several studies have shown that increasing choline intake has important benefits, such as decreased risk for heart disease,13 cancer14 and nonalcoholic fatty liver disease.15 Based on these findings, you’d be better off increasing your dietary choline intake, and the best sources include grass fed meat and milk, as well as pastured eggs.
Address the Root of Cancer — Poor Mitochondrial Health
I believe that virtually all major diseases like cancer, heart disease and obesity are linked to an inability to produce cellular energy due to impaired mitochondrial function. Without optimal cellular energy, your body cannot properly initiate the repair processes essential to preventing and recovering from disease.
Through the years, I’ve identified three pernicious toxins that damage your mitochondrial function, mainly by affecting intracellular calcium that subsequently impact your cellular health. In essence, exposure to these toxins raise intracellular calcium, which results in increased superoxide and nitric oxide levels. These combine into peroxynitrite, a potent reactive oxygen species that contributes to poor health. These three primary culprits are:
- Excess linoleic acid (LA) intake — An omega-6 polyunsaturated fat (PUFA), LA is abundantly found in seed and vegetable oils as well as ultraprocessed foods, and is one of most harmful ingredients in the Western diet. When consumed in excess, it negatively affects your metabolic rate and gut microbiome, which are the two of the most important factors that impact your health.
- Endocrine-disrupting chemicals (EDC) — Exposure to EDCs from sources like microplastics is over-activating your estrogen receptors. Microplastics are so pervasive that you’re probably eating a credit card’s worth of plastic every week.16 These plastics are loaded with phthalates and bisphenol A (BPA), which activate estrogen receptors. Estrogen increases intracellular calcium levels, which results in the generation of peroxynitrite.
- Excessive electromagnetic field (EMF) exposure — People are bombarded with EMFs, such as from cellphones, every day with hidden consequences to public health. EMFs activate voltage-gated calcium channel (VGCC) receptors within the cell, catalyzing the production of peroxynitrite by triggering an influx of calcium.
Addressing these three factors will help repair and return your mitochondrial function back on track to producing optimal cellular energy. Ultimately, this is the crucial first step to warding off all chronic disease that plague Americans today, such as cancer, and the best way to do it is limiting your exposure to them. To start, I recommend minimizing your LA intake below 5 grams from all dietary sources. If you can get it below 2 grams, that’s even better.
Next, minimize your EMF exposure by turning off the Wi-Fi and using hardwired connections instead. I also recommend using an analog alarm clock instead of relying on your phone’s alarm clock, which most people put beside their bed. The next strategy is reducing your exposure to plastics, which is accomplished by opting for products sold in glass containers and using reusable products over single-use ones.
This is just a preview of the strategies available to restore and repair your mitochondrial function. My newest book, “Your Guide to Cellular Health: Unlocking the Science of Longevity and Joy,” goes into great detail about how these three factors affect your mitochondrial function, as well as practical, healthy strategies to address them.
The eBook is now available, while the print edition will be released on December 10, 2024. I encourage you to pick up a copy, as this contains my latest research that corrects many long-held beliefs I’ve had in the previous years.
Another Anticancer Tip — Aspirin
In addition to addressing the main factors of mitochondrial function, there are other strategies available to help you prevent cancer. One approach is taking aspirin, a drug well-known for its pain-relieving and anti-inflammatory uses.
In my interview with bioenergetic medicine expert Georgi Dinkov, he discusses research using a combination of B vitamins and aspirin against a highly lethal form of human mantle cell lymphoma. He discovered that while the vitamins stopped tumor growth, adding aspirin into the equation regressed the tumor in the animal test subjects. Below, he explains the theoretical basis:
“One of Ray [Peat]’s main theories was that … cancer cells … [are] metabolically dysfunctional, we all know that, and typically a cell like that commits apoptosis. But in order to commit apoptosis, that mechanism is controlled almost entirely by the intracellular pH. And in order for apoptosis to occur, it needs to be in the acidic range.
But the cancer cells are alkaline due to exporting lactate and hydrogen ions. So, if anything can drop the intracellular pH, those cancer cells, because they’re deranged, should actually disappear by themselves.
And one of Peat’s suggestions at the time was, ‘Why don’t you use the drug acetazolamide?’ which as a carbonic anhydrase inhibitor, increases carbon dioxide. Carbon dioxide is acidic, and then that should allow cancer cells to commit apoptosis.
There are some studies in vitro and in vivo showing that acetazolamide may work, but it didn’t really cure the tumors. It was a slower growth, partial regression, but it showed that the idea was on the right track.
So, I said, ‘Let’s find something that’s much more acidic than carbon dioxide.’ And that is this 2,6-dihydroxybenzoic acid, which is just one extra hydroxyl group on top of aspirin. Salicylic acid, really, which is 2-hydroxybenzoic acid. And then this thing is about 10 times more potent than aspirin.”
That said, consider adding aspirin into your health routine. But don’t just select any aspirin available — opt for immediate-release formulations instead of the coated extended-release varieties. Pay attention to the ingredients as well. Ideally, corn starch should be the only additive listed.
After doing my own research, I identified a product meeting these criteria. The appropriate dosage ranges from 82 mg to 325 mg daily, taken with your largest meal, depending on your individual needs.
In the context of cancer prevention, the dosage and duration of aspirin are crucial factors. Low doses (75 to 300 mg/day) have been shown to be as effective as higher doses in reducing colorectal cancer-related mortality,17 which means there’s no need to take large amounts to gain the benefits.
Consistency and long-term use seem to be key, however. Studies indicate that aspirin’s benefits increase with duration, with significant reductions in cancer risk observed after five to 7.5 years of consistent use.18
I personally take 111 mg daily using Health Natura’s USP grade 60 gram aspirin powder, which costs less than $20. This 99% pure USP aspirin powder appeals to me due to its prometabolic, antilipolytic, anti-inflammatory, anticortisol and anti-estrogen effects. Its safety profile is also well-established.
- 1, 2 American Cancer Society, “Key Statistics for Prostate Cancer”
- 3 National Cancer Institute, “Cancer Stat Facts: Prostate Cancer”
- 4 Nat Genet. 2024 Sep 9. doi: 10.1038/s41588-024-01893-6, Abstract
- 5 Britannica, “Androgen”
- 6 Cleveland Clinic, “Androgens”
- 7 MedlinePlus, “AR Gene”
- 8 Nat Genet. 2024 Sep 9. doi: 10.1038/s41588-024-01893-6, Main
- 9 Nat Genet. 2024 Sep 9. doi: 10.1038/s41588-024-01893-6, Ethical Statement
- 10 Nat Genet. 2024 Sep 9. doi: 10.1038/s41588-024-01893-6, Functional CRISPR Screen Reveals NSD2 as an AR Coactivator
- 11 Michigan Medicine, September 9, 2024
- 12 American Journal of Clinical Nutrition 2012 Oct; 96(4): 855–863, Abstract
- 13 Nutrients. 2023 Sep; 15(18): 4036, Abstract
- 14 Scientific Reports, volume 13, Article number: 22144 (2023), Abstract
- 15 European Journal of Clinical Nutrition, volume 77, pages 1160–1166 (2023), Abstract
- 16 World Wildlife Fund, Assessing Plastic Ingestion from Nature to People, page 7
- 17, 18 Cureus. 2024 Feb; 16(2): e54658, Review
Five Things New “Preppers” Forget When Getting Ready for Bad Times Ahead
The preparedness community is growing faster than it has in decades. Even during peak times such as Y2K, the economic downturn of 2008, and Covid, the vast majority of Americans made sure they had plenty of toilet paper but didn’t really stockpile anything else.
Things have changed. There’s a growing anxiety in this presidential election year that has prompted more Americans to get prepared for crazy events in the future. Some of it is being driven by fearmongers, but there are valid concerns with the economy, food supply, pharmaceuticals, the energy grid, and mass rioting that have pushed average Americans into “prepper” mode.
There are degrees of preparedness. One does not have to be a full-blown “doomsday prepper” living off-grid in a secure Montana bunker in order to be ahead of the curve. In many ways, preparedness isn’t about being able to perfectly handle every conceivable situation. It’s about being less dependent on government for as long as possible. Those who have proper “preps” will not be waiting for FEMA to distribute emergency supplies to the desperate masses.
Below are five things people new to preparedness (and sometimes even those with experience) often forget as they get ready. All five are common sense notions that do not rely on doomsday in order to be useful. It may be nice to own a tank during the apocalypse but there’s not much you can do with it until things get really crazy. The recommendations below can have places in the lives of average Americans whether doomsday comes or not.
Note: The information provided by this publication or any related communications is for informational purposes only and should not be considered as financial advice. We do not provide personalized investment, financial, or legal advice.
Secured Wealth
Whether in the bank or held in a retirement account, most Americans feel that their life’s savings is relatively secure. At least they did until the last couple of years when de-banking, geopolitical turmoil, and the threat of Central Bank Digital Currencies reared their ugly heads.
It behooves Americans to diversify their holdings. If there’s a triggering event or series of events that cripple the financial systems or devalue the U.S. Dollar, wealth can evaporate quickly. To hedge against potential turmoil, many Americans are looking in two directions: Crypto and physical precious metals.
There are huge advantages to cryptocurrencies, but there are also inherent risks because “virtual” money can become challenging to spend. Add in the push by central banks and governments to regulate or even replace cryptocurrencies with their own versions they control and the risks amplify. There’s nothing wrong with cryptocurrencies today but things can change rapidly.
As for physical precious metals, many Americans pay cash to keep plenty on hand in their safe. Rolling over or transferring retirement accounts into self-directed IRAs is also a popular option, but there are caveats. It can often take weeks or even months to get the gold and silver shipped if the owner chooses to close their account. This is why Genesis Gold Group stands out. Their relationship with the depositories allows for rapid closure and shipping, often in less than 10 days from the time the account holder makes their move. This can come in handy if things appear to be heading south.
Lots of Potable Water
One of the biggest shocks that hit new preppers is understanding how much potable water they need in order to survive. Experts claim one gallon of water per person per day is necessary. Even the most conservative estimates put it at over half-a-gallon. That means that for a family of four, they’ll need around 120 gallons of water to survive for a month if the taps turn off and the stores empty out.
Being near a fresh water source, whether it’s a river, lake, or well, is a best practice among experienced preppers. It’s necessary to have a water filter as well, even if the taps are still working. Many refuse to drink tap water even when there is no emergency. Berkey was our previous favorite but they’re under attack from regulators so the Alexapure systems are solid replacements.
For those in the city or away from fresh water sources, storage is the best option. This can be challenging because proper water storage containers take up a lot of room and are difficult to move if the need arises. For “bug in” situations, having a larger container that stores hundreds or even thousands of gallons is better than stacking 1-5 gallon containers. Unfortunately, they won’t be easily transportable and they can cost a lot to install.
Water is critical. If chaos erupts and water infrastructure is compromised, having a large backup supply can be lifesaving.
Pharmaceuticals and Medical Supplies
There are multiple threats specific to the medical supply chain. With Chinese and Indian imports accounting for over 90% of pharmaceutical ingredients in the United States, deteriorating relations could make it impossible to get the medicines and antibiotics many of us need.
Stocking up many prescription medications can be hard. Doctors generally do not like to prescribe large batches of drugs even if they are shelf-stable for extended periods of time. It is a best practice to ask your doctor if they can prescribe a larger amount. Today, some are sympathetic to concerns about pharmacies running out or becoming inaccessible. Tell them your concerns. It’s worth a shot. The worst they can do is say no.
If your doctor is unwilling to help you stock up on medicines, then Jase Medical is a good alternative. Through telehealth, they can prescribe daily meds or antibiotics that are shipped to your door. As proponents of medical freedom, they empathize with those who want to have enough medical supplies on hand in case things go wrong.
Energy Sources
The vast majority of Americans are locked into the grid. This has proven to be a massive liability when the grid goes down. Unfortunately, there are no inexpensive remedies.
Those living off-grid had to either spend a lot of money or effort (or both) to get their alternative energy sources like solar set up. For those who do not want to go so far, it’s still a best practice to have backup power sources. Diesel generators and portable solar panels are the two most popular, and while they’re not inexpensive they are not out of reach of most Americans who are concerned about being without power for extended periods of time.
Natural gas is another necessity for many, but that’s far more challenging to replace. Having alternatives for heating and cooking that can be powered if gas and electric grids go down is important. Have a backup for items that require power such as manual can openers. If you’re stuck eating canned foods for a while and all you have is an electric opener, you’ll have problems.
Don’t Forget the Protein
When most think about “prepping,” they think about their food supply. More Americans are turning to gardening and homesteading as ways to produce their own food. Others are working with local farmers and ranchers to purchase directly from the sources. This is a good idea whether doomsday comes or not, but it’s particularly important if the food supply chain is broken.
Most grocery stores have about one to two weeks worth of food, as do most American households. Grocers rely heavily on truckers to receive their ongoing shipments. In a crisis, the current process can fail. It behooves Americans for multiple reasons to localize their food purchases as much as possible.
Long-term storage is another popular option. Canned foods, MREs, and freeze dried meals are selling out quickly even as prices rise. But one component that is conspicuously absent in shelf-stable food is high-quality protein. Most survival food companies offer low quality “protein buckets” or cans of meat, but they are often barely edible.
Prepper All-Naturals offers premium cuts of steak that have been cooked sous vide and freeze dried to give them a 25-year shelf life. They offer Ribeye, NY Strip, and Tenderloin among others.
Having buckets of beans and rice is a good start, but keeping a solid supply of high-quality protein isn’t just healthier. It can help a family maintain normalcy through crises.
Prepare Without Fear
With all the challenges we face as Americans today, it can be emotionally draining. Citizens are scared and there’s nothing irrational about their concerns. Being prepared and making lifestyle changes to secure necessities can go a long way toward overcoming the fears that plague us. We should hope and pray for the best but prepare for the worst. And if the worst does come, then knowing we did what we could to be ready for it will help us face those challenges with confidence.